Why Is Inherited Thrombophilia Important?

Inherited thrombophilia is an excessive clotting tendency caused by genetic mutations passed down through families.

Risk Factors

The most common genetic mutations in inherited thrombophilia:

• Factor V Leiden: the most common inherited cause
• Prothrombin gene mutation (G20210A): the second most common mutation
• MTHFR mutations: affect homocysteine metabolism
• Protein C and Protein S deficiency: rare but high risk

Clinical Significance

Inherited thrombophilia:

1. Increases the risk of deep vein thrombosis (DVT)
2. Raises the risk of pulmonary embolism
3. Can cause recurrent pregnancy loss
4. May be associated with preeclampsia and IUGR

The Importance of Early Diagnosis

In individuals diagnosed with inherited thrombophilia, pregnancy complications can be significantly reduced with appropriate preventive treatment.